Monascus pigment prevent the oxidative cytotoxicity in Myotube derived hydrogen peroxide

The amounts of Reactive oxygen species (ROS) become higher by strenuous exercises which consume larger in active muscles. Since these ROS directly injured muscles, the high concentration involves muscle fatigue. Thus, an immediate scavenging system is desired. Monascus pigment (MP) physiologically substances scavenge ROS, it may be a clue to save injury. However, there are no reports examining MP effects on oxidative stress skeletal muscle. In this study, we investigated effect and mechanism cells damaged stress. ability eliminate was evaluated mixing solutions with ・OH O2・−, type ROS. peroxidation C2C12 cell viability assay or western blotting. scavenges O2・−. treatment increases survival rate under At that time, expression catalase, antioxidant enzyme, increased: enzyme change H2O2 into H2O rescue We conclude monascus suppressed myotube damage both non-enzymatic up-regulation catalase expression.